CD14 gene-159C/T polymorphism and coronary artery disease: a meta-analysis involving 4467 subjects.

BACKGROUND The cluster of differentiation antigen 14 (CD14) gene-159C/T polymorphism has been implied to be associated with coronary artery disease (CAD) susceptibility. However, the separate studies results are still conflicting between each other. OBJECTIVE AND METHODS To investigate the relationship between CD14 gene-159C/T polymorphism and CAD, a meta-analysis including 4467 subjects from 7 individual studies was performed. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals. RESULTS There was a significant association between CD14 gene -159C/T polymorphism and CAD in the whole population under allelic (OR: 1.280, 95% CI: 1.000-1.630, P=0.05), recessive (OR: 1.760, 95% CI: 1.120-2.750, P=0.01), homozygous (OR: 1.693, 95% CI: 1.008-2.843, P=0.046), and additive genetic models (OR: 1.278, 95% CI: 1.000-1.633, P=0.050). No significant association was found between them under dominant (OR: 0.580, 95% CI: 0.310-1.110, P=0.10) and heterozygous genetic models (OR: 1.334, 95% CI: 0.870-2.045, P=0.186). In the subgroup analysis, a significant association was detected in Chinese population (P<0.05), while there was no significant association in the Caucasian subgroup (P>0.05). CONCLUSIONS CD14 gene -159C/T polymorphism was significantly associated with CAD susceptibility, particularly in the Chinese population. The person with T allele of CD14 gene -159C/T polymorphism might predispose to CAD. There was no distinct association between them in the Caucasian subgroup.